Hyperimmune Response
It’s been a frustrating journey with most doctors gaslighting us because standard blood tests show no abnormalities. Progress with more specialized, local care is still a long road ahead but I’m happy to share a glimmer of hope within cutting edge research.
A hilariously frustrating yet validating week.
Primary Care - Referral for Orthopedic Specialist (hand).
Follow-up from bloodwork. Everything looks normal except: Iron is low, Vitamin D is low, and Ferritin is low
Physical Therapy - Strengthening upper back and shoulder (for the last 4 years)
Neurology - check-in after fainting episode in February
GYNO - IUD removal after 4 years of birth control—liberating myself from all medications to return to a baseline.
I once hit the panic button during an MRI because I felt my IUD vibrating (magnets!). This could have been a fatal mistake. The tech insisted I hadn’t disclosed it on the intake form—even though I absolutely had. Instead of adjusting the machine, they blamed me and told me to pick up a Valium prescription for the rescheduled appointment. lololol
For the most part, American doctors are behind the curve. Patients are having to educate themselves on clinical terms to accurately convey what is happening to their bodies to get the acute care they need. But I don’t want to be a biologist or a doctor. I’m tired and I’d rather save my energy for other things.
In June, a phlebotomist came to my home and drew blood like some old-timey doctor making house calls, arriving with a medicine bag. That blood sample went to a lab in the UK. Two weeks ago, I received those results. My body is producing an abnormal amount of antibodies. And some of those antibodies are low in quality. Destructive monsters.
Last week, the Attomarker Results were presented in a public forum. The information was dense but this cutting edge research can tell if someone’s immune system responded to Covid or the vaccine as normal / autoimmune / hyperimmune / hyper autoimmune based on the spike proteins timestamped by specific mutations of the Covid virus. My results are proving a hyperimmune response but awaiting further confirmation. Hypothetically, this information can inform treatment. This is light years ahead of American healthcare but they are currently seeking approval with the FDA.
The following is a combination of audio recording > transcript > cleaned up and summarized by AI.
AttoMarker & Antibody Testing
Guest: Dr. Andrew Shaw, Professor
Host: Dr. Mobeen Syed
1. Introduction & Context
AttoMarker is a UK-based diagnostic tool that measures:
Antibody concentration and quality.
Responses to 15 SARS-CoV-2 variants, from Wuhan to XEC.
MHRA registered and UKCA marked in the UK; FDA approval pending.
Primary aim: support long COVID and vaccine-injured patients by identifying immune response patterns.
Seeks to build a U.S. clinical network to interpret test results and guide treatment.
2. Blood Circulation & Systemic Impact
Blood circulation plays a central role in transporting:
Viral particles (including spike protein).
Vaccine-derived mRNA.
Antibodies throughout the body.
Once in circulation, spike protein can bind to ACE2 receptors in diverse organs (heart, liver, brain, gut).
Circulating spike protein may persist post-infection or vaccination, contributing to:
Immune system confusion.
Multi-organ symptoms in long COVID or vaccine injury.
This systemic exposure is one reason for the diversity of symptoms and complexity of treatment.
3. Theories Behind Long COVID & Vaccine Injury
A. Persistent Viral Reservoirs
Virus may hide in organs and continue producing spike protein.
Ongoing immune responses result in symptoms, even if PCR tests are negative.
B. Immune Dysregulation
Some patients are:
Immunocompromised – weak antibody response.
Hyperimmune – excessive, potentially autoimmune antibody activity.
Spike protein generated from mRNA vaccines may travel via bloodstream and lodge in unintended tissues, possibly triggering immune attack.
4. How the AttoMarker Test Works
A. What It Measures
Antibody concentration (mg/L) and quality of binding.
Across 15 spike variants, plus nucleocapsid protein (to confirm prior infection).
B. Method & Analysis
Uses blood serum to track antibody binding strength and duration.
Also assesses function at different pH levels (e.g., acidic gut vs. neutral blood).
C. Immune Patterns
Three distinct immune response types:
Normal – broad, effective antibody profile.
Gapped – missing response to certain variants.
Hyperimmune – abnormally high antibody levels, often long after infection or vaccination.
5. Patient Case Findings
A. U.S. Cohort Highlights
Patients often show:
Low antibody quality to newer variants (e.g., XEC).
Some have no detectable response, even if vaccinated or infected.
Hyperimmune cases show massive, persistent antibody levels. These aren’t the protective kind of antibodies we celebrate. They're excessive, poorly targeted, and can wreak havoc—especially if the spike protein is lingering in circulation.
B. Biphasic Immune Response
Some individuals show both suppressed and overactive traits—a pattern not seen in earlier UK cases.
Dr. Shaw refers to this as a new, fourth category under investigation.
6. Virus Structure & Host Interaction
Spike proteins attach to ACE2 receptors, found throughout the body:
Lungs, gut, brain, heart, kidneys, and blood-brain barrier.
Once in systemic circulation, spike proteins can affect these organs directly.
This distribution helps explain over 250 reported symptoms of long COVID.
7. Regulatory Status & Forward Plans
UK: Fully operational through private clinics.
U.S.: FDA application in progress; may qualify as a breakthrough device.
Dr. Shaw aims to:
Publish findings in peer-reviewed journals.
Partner with U.S. doctors for clinical interpretation and patient care.
8. Clinical Applications & Future Vision
Test provides a functional antibody profile, offering insight into:
Persistent viral activity.
Autoimmune reactions.
Post-vaccine complications.
Designed as a clinical support tool, not a standalone diagnostic.
Encourages treatment decisions based on immune profiles, history, and symptoms.
9. Final Takeaways
AttoMarker reveals how the body has interacted with SARS-CoV-2 and vaccines through detailed immune analysis.
Emphasizes the role of circulating spike proteins and systemic immune effects.
Valuable for clinicians treating long COVID, ME/CFS, and potential vaccine-related complications.
I don’t have all the answers yet, and U.S. care feels like climbing a mountain barefoot. But these results offer validation. My immune system has been yelling—and technology is finally being developed to listen. But my time in Los Angeles is expiring at the end of this month. I look forward to realigning myself to nature and the universe through meditation and craft. Visit me on the astral plane also known as Joshua Tree, CA.
Update July 28, 2025
Attomarker sent a report on the classification of my test results. Turns out there is Hyperimmunity for the Alpha and Delta variants and Hypoimmune/Immuno-compromised for the following variants: BA.1, BA.2, BA.5, BA.2.12.1, KP.3, XEC
